Spermidine+

Rated 5.0 out of 5
Based on 30 reviews

Boosts the Cell Renewal Process*
Promotes Longevity*
Promotes Healthier Aging*

A compound linked to longevity.*

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"My wife and I started with a different brand but prefer this one."

Mark R.

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average rating 5.0 out of 5
Based on 30 reviews
  • 5 Stars
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100% of reviewers would recommend this product to a friend
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Review posted
Reviewed by Kunk F., from United States
Verified Buyer
Rated 5 out of 5

Would recommend for long term use for full benefit

I strongly believe it is important to supplement our diet with high quality vitamins, minerals etc for various reasons and this product does not disappoint. The biggest change I’ve noticed since taking this product I the reduction of fatigue. I have also been able to fall asleep more easily, and even get up in the morning more easily.

The capsules are easy to swallow, and as someone who is picky about what is in the foods/products I consume, this one fits the bill.

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Reviewed by Amazon C., from United States
Verified Buyer
Rated 5 out of 5

This is actually working!!

I was skeptical at first, like I am with most supplement companies and products, you never know what fillers companies can add in, but after doing some research this seemed worth a try. I have to say I am blown away, it’s clean, easy to take and actually works. I take a variety of supplements on a daily basis and I am extremely proud I found this one to add into the mix!! Please come out with more supplements, I will try them all!!

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Reviewed by sarah j., from United States
Verified Buyer
Rated 5 out of 5

Best Probiotic I have tried.

Have been taking this new probiotic for a week and have noticed a difference in that I haven t experienced any bloating or cramps. They are easy to swallow and I like that I can empty the contents into my smoothy:)

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Reviewed by danielle l., from United States
Verified Buyer
Rated 5 out of 5

Easy to take, feel like it’s working

After a couple weeks I definitely feel like my energy levels are increased and I’ve also had better sleep!

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References

  1. Madeo F, et al. Spermidine delays aging in humans. Aging. 2018.
  2.  Madeo F, Bauer MA, Carmona-Gutierrez D, Kroemer G. Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Autophagy. 2019.
  3.  Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G. Spermidine: a novel autophagy inducer and longevity elixir. Autophagy. 2010.
  4. Eisenberg T,et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009.
  5. Aman Y, Schmauck-Medina T, et al. Autophagy in healthy aging and disease. Nat Aging. 2021.
  6. Ni YQ, Liu YS. New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases. Aging Dis. 2021.
  7. Ghosh I, et al. Spermidine, an autophagy inducer, as a therapeutic strategy in neurological disorders. Neuropeptides. 2020.
  8. Gupta VK, et al. Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner. Nat Neurosci. 2013.
  9. Yang, Xin et al. Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans. Aging. 2020.
  10. Büttner S, et al. Spermidine protects against α-synuclein neurotoxicity. Cell Cycle. 2014.
  11. Kiechl S, et al. Higher spermidine intake is linked to lower mortality: a prospective population-based study. Amer J Cli Nutr. 2018.
  12.  Eisenberg T, et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016.
  13. LaRocca TJ,et al. The autophagy enhancer spermidine reverses arterial aging. Mech Ageing Dev. 2013.
  14. Willeit P, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA. 2010.
  15. Gupta VK, et al. Spermidine suppresses age-associated memory impairment by preventing adverse increase of presynaptic active zone size and release. PLoS Biol. 2016.