Fisetin

Rated 4.9 out of 5
Based on 106 reviews

Manages Senescent Cells*
Promotes Cognitive Function*
High Dose of 500mg per capsule!

Manages senescent cells and provides premier antioxidant support.*

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    "Originally the amount of fisetin was why I got it. I’ll keep taking it since it’s been helpful. "

    James B.

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    average rating 4.9 out of 5
    Based on 106 reviews
    • 5 Stars
      102 Reviews
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    98% of reviewers would recommend this product to a friend
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    Review posted
    Reviewed by Redhorses, from United States
    Verified Buyer
    Rated 5 out of 5

    Even my doctor thinks it works

    I wasn't sure if this was a good plan or not for pain. I have chronic and severe pain. I go to a pain specialistand the last time I went, I told her I was taking this Fiseton and asked what she thought. She said she had patients that have used it and after three months began to lower their other meds because they found it so helpful. I haven't taken it that long but I am going to. And probably longer.

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    Reviewed by Liz E., from United States
    Verified Buyer
    Rated 5 out of 5

    It was ordered by my doctor this is the most value for money

    It's is what was ordered it it the most value for the money

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    Reviewed by richard n., from United States
    Verified Buyer
    Rated 5 out of 5

    Great value

    brain health!

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    Review posted
    Reviewed by M. C., from United States
    Verified Buyer
    Rated 5 out of 5

    Excellent product

    This is a good quality product and a good price.

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    References

    1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018.
    2. Maher P. How fisetin reduces the impact of age and disease on CNS function. Front Biosci (Schol Ed) 2015.
    3. Adhami V.M., Syed D.N., Khan N., Mukhtar H. Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem Pharmacol. 2012.
    4. Zhu Y., Doornebal E.J., Pirtskhalava T., Giorgadze N., Wentworth M., Fuhrmann-Stroissnigg H. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY). 2017.
    5. Kirkland J.L., Tchkonia T., Zhu Y., Niedernhofer L.J., Robbins P.D. The clinical potential of senolytic drugs. J Am Geriatr Soc. 2017.
    6. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013.
    7. Ishige K. Schubert D. Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med. 2001.
    8. Lee SE. Jeong SI. Yang H. Park CS. Jin YH. Park YS. Fisetin induces Nrf2-mediated HO-1 expression through PKC-delta and p38 in human umbilical vein endothelial cells. J Cell Biochem. 2011.
    9. Maher P. Dargusch R. Bodai L. Gerard PE. Purcell JM. Marsh JL. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum Mol Genet. 2011.
    10. Syed DN, Adhami VM, Khan MI, Mukhtar H. Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anticancer Agents Med Chem. 2013.
    11. Sun X, Ma X, Li Q, Yang Y, Xu X, Sun J, Yu M, Cao K, Yang L, Yang G, Zhang G, Wang X. Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In vitro and in vivo studies. Int J Mol Med. 2018.
    12. Maher P, Akaishi T, Abe K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A. 2016.
    13. He WB, Abe K, Akaishi T. Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo. J Pharmacol Sci. 2018.
    14. Maher P. Preventing and Treating Neurological Disorders with the Flavonol Fisetin. Brain Plast. 2021.
    15. Ravula AR, Teegala SB, Kalakotla S, Pasangulapati JP, Perumal V, Boyina HK. Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review. Eur J Pharmacol. 2021.
    16. Gasek, N.S., Kuchel, G.A., Kirkland, J.L. et al.Strategies for targeting senescent cells in human disease. Nat Aging. 2021.
    17. Kubo, Chisato, et al. Fisetin promotes hair growth by augmenting TERT expression. Frontiers in Cell and Developmental Biology. 2020. 
    18. Zhu M, Meng P, Ling X, Zhou L. Advancements in therapeutic drugs targeting of senescence. Therapeutic Advances in Chronic Disease. 2020.
    19. Chuang JY, Chang PC, et al. Regulatory effects of fisetin on microglial activation. Molecules. 2014.
    20. Iside C, Scafuro M, Nebbioso A, Altucci L. SIRT1 Activation by Natural Phytochemicals: An Overview. Front Pharmacol. 2020.