Fisetin

Rated 4.9 out of 5
Based on 84 reviews

Removes Senescent Cells*
Promotes Cognitive Function*
High Dose of 500mg per capsule!

Removes senescent cells and provides powerful antioxidant support.*

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    "Originally the amount of fisetin was why I got it. I’ll keep taking it since it’s been helpful. "

    James B.

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    average rating 4.9 out of 5
    Based on 84 reviews
    • 5 Stars
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    98% of reviewers would recommend this product to a friend
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    Review posted
    Reviewed by Joasia1431, from United States
    Verified Buyer
    Rated 5 out of 5

    Wow it's like aging backwards!

    It s like going back in time in terms of mental sharpness. I have found that since I started taking this I am not searching for words as often as I used to and I overall just feel more alert and focused. I am so excited to have found this product and feel like I just took 20 years off my cognitive state! I m going to be telling everyone about this.

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    Reviewed by Amazon C., from United States
    Verified Buyer
    Rated 5 out of 5

    My brain is improving

    This product has given me a very noticeable difference in brain functionality. Also with the antioxidants cleansing my system I feel great too. I will definitely be purchasing more of there products in the future.

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    Review posted
    Reviewed by Jen G., from United States
    Verified Buyer
    Rated 5 out of 5

    Antioxidant and anti-inflammatory winner

    I purchased this product to enhance antioxidant products i take for allergies and am loving it! I also have arthritis so I'm excited that it is an anti-inflammatory as well. Love the light-block bottle and the taste is fine. Good stuff!

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    Review posted
    Reviewed by Amazon C., from United States
    Verified Buyer
    Rated 5 out of 5

    Amazing I can breath

    These pill are so easy to swallow I saw immediately the results I felt like I cold breath way better

    Definitely recommend they are amazing ????????

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    References

    1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018.
    2. Maher P. How fisetin reduces the impact of age and disease on CNS function. Front Biosci (Schol Ed) 2015.
    3. Adhami V.M., Syed D.N., Khan N., Mukhtar H. Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem Pharmacol. 2012.
    4. Zhu Y., Doornebal E.J., Pirtskhalava T., Giorgadze N., Wentworth M., Fuhrmann-Stroissnigg H. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY). 2017.
    5. Kirkland J.L., Tchkonia T., Zhu Y., Niedernhofer L.J., Robbins P.D. The clinical potential of senolytic drugs. J Am Geriatr Soc. 2017.
    6. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. 2013.
    7. Ishige K. Schubert D. Sagara Y. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med. 2001.
    8. Lee SE. Jeong SI. Yang H. Park CS. Jin YH. Park YS. Fisetin induces Nrf2-mediated HO-1 expression through PKC-delta and p38 in human umbilical vein endothelial cells. J Cell Biochem. 2011.
    9. Maher P. Dargusch R. Bodai L. Gerard PE. Purcell JM. Marsh JL. ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum Mol Genet. 2011.
    10. Syed DN, Adhami VM, Khan MI, Mukhtar H. Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anticancer Agents Med Chem. 2013.
    11. Sun X, Ma X, Li Q, Yang Y, Xu X, Sun J, Yu M, Cao K, Yang L, Yang G, Zhang G, Wang X. Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In vitro and in vivo studies. Int J Mol Med. 2018.
    12. Maher P, Akaishi T, Abe K. Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory. Proc Natl Acad Sci U S A. 2016.
    13. He WB, Abe K, Akaishi T. Oral administration of fisetin promotes the induction of hippocampal long-term potentiation in vivo. J Pharmacol Sci. 2018.
    14. Maher P. Preventing and Treating Neurological Disorders with the Flavonol Fisetin. Brain Plast. 2021.
    15. Ravula AR, Teegala SB, Kalakotla S, Pasangulapati JP, Perumal V, Boyina HK. Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review. Eur J Pharmacol. 2021.
    16. Gasek, N.S., Kuchel, G.A., Kirkland, J.L. et al.Strategies for targeting senescent cells in human disease. Nat Aging. 2021.
    17. Kubo, Chisato, et al. Fisetin promotes hair growth by augmenting TERT expression. Frontiers in Cell and Developmental Biology. 2020. 
    18. Zhu M, Meng P, Ling X, Zhou L. Advancements in therapeutic drugs targeting of senescence. Therapeutic Advances in Chronic Disease. 2020.
    19. Chuang JY, Chang PC, et al. Regulatory effects of fisetin on microglial activation. Molecules. 2014.
    20. Iside C, Scafuro M, Nebbioso A, Altucci L. SIRT1 Activation by Natural Phytochemicals: An Overview. Front Pharmacol. 2020.