Pterostilbene

Supports Cognitive Function*
Premier Antioxidant*
Anti-Inflammatory*

Pterostilbene supports brain function by supporting activation of CREB, a cellular transcription factor associated with memory formation.*

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    "Max mg I could find from a reputable brand gave me reassurance. This outdoes the resveratrol I took before. "

    Colleen S.

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    References

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    2. Kapetanovic I.M., Muzzio M., Huang Z., Thompson T.N., McCormick D.L. Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats.  Cancer Chemotherapy and Pharmacology. 2011.
    3. Casadesus G., Shukitt-Hale B., Stellwagen H.M., Zhu X., Lee H.G., Smith M.A., Joseph J.A. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats.  Nutritional Neuroscience. 2004.
    4. Wang B., Liu H., Yue L., Li X., Zhao L., Yang X., Wang X., Yang Y., Qu Y. Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway.  Brain Research. 2016.
    5. Rendeiro C., Vauzour D., Kean R.J., Butler L.T., Rattray M., Spencer J.P., Williams C.M. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats.  Psychopharmacology (Berlin). 2012.
    6. Estrada N.M., Isokawa M. Metabolic Demand Stimulates CREB Signaling in the Limbic Cortex: Implication for the Induction of Hippocampal Synaptic Plasticity by Intrinsic Stimulus for Survival. Frontiers in Systems Neuroscience. 2009.
    7. Silva AJ, Kogan JH, Frankland PW, Kida S. CREB and memory. Annu Rev Neurosci. 1998.
    8. Williams C.M., El Mohsen M.A., Vauzour D., Rendeiro C., Butler L.T., Ellis J.A., Whiteman M., Spencer J.P. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radical Biology and Medicine. 2008.
    9. Joseph JA, Fisher DR, Cheng V, Rimando AM, Shukitt-Hale B. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. J Agric Food Chem. 2008.
    10. Al Rahim M., Rimando A.M., Silistreli K., El-Alfy A.T.  Anxiolytic action of pterostilbene: involvement of hippocampal ERK phosphorylation.  Planta Medica. 2013.
    11. Einat H., et. Al. The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation  The Journal of Neuroscience. 2003.
    12. Chang J., Rimando A., Pallas M., Camins A., Porquet D., Reeves J., Shukitt-Hale B., Smith M.A., Joseph J.A., Casadesus G. Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer’s disease.  Neurobiology Aging. 2012.
    13. Ren G, Rimando AM, Mathews ST. AMPK activation by pterostilbene contributes to suppression of hepatic gluconeogenic gene expression and glucose production in H4IIE cells. Biochem Biophys Res Commun. 2018.
    14. Liu D, Ma Z, Xu L, Zhang X, Qiao S, Yuan J. PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades. Aging. 2019.
    15. Kosuru R, Rai U, Prakash S, Singh A, Singh S. Promising therapeutic potential of pterostilbene and its mechanistic insight based on preclinical evidence. Eur J Pharmacol. 2016.
    16. Li YR, Li S, Lin CC. Effect of resveratrol and pterostilbene on aging and longevity. Biofactors.  2018.
    17. Salt IP, Hardie DG. AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System. Circ Res. 2017.
    18. Chen R, et al. Autophagy-inducing effect of pterostilbene: a prospective therapeutic/ preventive option for skin diseases. J Food Dr An. 2017.
    19. Zhou J, et al. Pterostilbene activated the nrf2-dependant antioxidant response to ameliorate arsenic- induced intracellular damage and apoptosis in human keratinocytes. Front Pharmacol. 2019.
    20. Jayakumar T, et al. Involvement of antioxidant defenses and NF-KB/ERK signalling in anti- inflammatory effects of pterostilbene, a natural analogue of resveratrol. Applied Sci. 2021.